2020-RAHI-68984: Wearable, portable invention to treat antibiotic-resistant infections, wounds

PROBLEM

Surgical mesh is used to prevent bacteria and carry oxygen, especially for surgical wound sites. Current mesh technologies are often expensive, however, and can lead to long-term post-surgical complications such as adverse bodily response to a foreign object.

SOLUTION

Purdue researchers have introduced a new solvent-free, cost-efficient, scalable process for making strong, flexible, biodegradable surgical mesh. This approach has been tested with various compositions of calcium peroxide on polymer fibers to develop a mesh with excellent oxygen permeability.

IN THE MEDIA 

Purdue University News Release

PRIMARY INVESTIGATOR 

Rahim Rahimi, assistant professor, School of Materials Engineering, College of Engineering

INNOVATION DISCLOSURE 

Resorbable Surgical Mesh Impregnated with Calcium Peroxide: 2020-RAHI-68984

LICENSING CONTACTS 

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org

MEDIA CONTACT 

Email Steve Martin


ABSTRACT

Resorbable Surgical Mesh Impregnated with Calcium Peroxide

Rahimi, Rahim(Project Leader), Woodhouse, Ian B, Zareei, Amin

Researchers at Purdue University have developed a new resorbable surgical mesh that is impregnated with calcium peroxide for regeneration of tissue at dermal wound sites. Surgical mesh is used to prevent bacteria and carry oxygen, especially for surgical wound sites however, current mesh technologies are often expensive and can lead to long-term post-surgical complications such as adverse bodily response to a foreign object. Purdue researchers introduce a new solvent-free, cost-efficient, scalable process for making strong, flexible, biodegradable surgical mesh. This approach has been tested with various compositions of calcium peroxide on polymer fibers to develop a mesh with optimal porosity, verified by scanning electron microscopy (SEM), which allows for excellent oxygen permeability. The new mesh was cultured with HMS-32 skin cells in vitro, exhibiting 90-92% cell viability as well as having ability to prevent necrosis by reducing hypoxia-induced cell death within six days.